Positive thinking

Sim K. Singhrao, University of Central Lancashire   For most people, teeth cleaning may just be a normal part of your daily routine. But what if the way you clean your teeth today, might affect your chances of getting Alzheimer’s disease in years to come? There is an increasing body of evidence to indicate that gum (periodontal) disease could be a plausible risk factor for Alzheimer’s disease. Some studies even suggest your risk doubles when gum disease persists for ten or more years. Indeed, a new US study published in Science Advances details how a type of bacteria called Porphyromonas gingivalis – or P. gingivalis – which is associated with gum disease, has been found in the brains of patients with Alzheimer’s disease. Tests on mice also showed how the bug spread from their mouth to the brain where it destroyed nerve cells. The report in question was carried out and self-funded by founders of a US pharmaceutical company Cortexyme , which is researching the cau...

Ruth Itzhaki, University of Manchester   More than 30m people worldwide suffer from Alzheimer’s disease – the most common form of dementia. Unfortunately, there is no cure, only drugs to ease the symptoms. However, my latest review , suggests a way to treat the disease. I found the strongest evidence yet that the herpes virus is a cause of Alzheimer’s, suggesting that effective and safe antiviral drugs might be able to treat the disease. We might even be able to vaccinate our children against it. The virus implicated in Alzheimer’s disease, herpes simplex virus type 1 (HSV1), is better known for causing cold sores. It infects most people in infancy and then remains dormant in the peripheral nervous system (the part of the nervous system that isn’t the brain and the spinal cord). Occasionally, if a person is stressed, the virus becomes activated and, in some people, it causes cold sores. We discovered in 1991 that in many elderly people HSV1 is also present in the br...